He was born in Baltimore.
In the mid-1870s his family moved to Newton Corner, where William's
father James established himself as a caterer. At 18, William won a
scholarship to attend the Cowles Art School, where he began his art studies with Dennis Miller Bunker. Later he studied with Jean-Léon Gérôme in Paris and, on his return to Boston, with Joseph DeCamp
at Cowles. There he met his future wife Elizabeth Okie, who also was
studying with DeCamp. After their marriage, William and Elizabeth lived
with his parents at 43 Elmwood Street, and later bought a house at 19
Montvale Road in Newton Centre.
Paxton, who is best known as a portrait painter, taught at the Museum School from 1906 to 1913. Along with other well-known artists of the era, including Edmund Charles Tarbell and Frank Weston Benson, he co-founded The Guild of Boston Artists
and he is identified with the Boston School. He was well known for his
extraordinary attention to the effects of light and detail in flesh and
fabric. Paxton's compositions were most often idealized young women in
beautiful interiors. Paxton gained fame for his portraiture and painted
both Grover Cleveland and Calvin Coolidge. He taught at the Boston Museum of Fine Arts School from 1906 to 1913. Paxton was made a full member of the National Academy of Design in 1928.
Like many of his Boston colleagues, Paxton found inspiration in the work of the seventeenth-century Dutch painter Johannes Vermeer.
Paxton was fascinated not only with Vermeer's imagery, but also with
the system of optics he employed. He studied Vermeer's works closely,
and discovered that only one area in his compositions was entirely in
focus, while the rest were somewhat blurred. Paxton ascribed this
peculiarity to "binocular vision," crediting Vermeer with recording the
slightly different point of view of each individual eye that combine in
human sight.
. He began to employ this system in his own work, including The New Necklace,
where only the gold beads are sharply defined while the rest of the
objects in the composition have softer, blurrier edges. This effect is
even more noticeable in Paxton's 1915 painting entitled Nude,
which shows a young woman seated on a blue dress that is spread across
the seat of a backless divan. The woman is shown leaning slightly to the
right, reaching for a pink undergarment. The figure is viewed from an
angle that is midway between a back view and a right side view.
All objects in the painting are slightly blurred with the exception of
the woman's one visible breast (the right one) and parts of her right
arm.
Paxton crafted his elaborate compositions with models in his studio,
and the props he used, appear in several different paintings.